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Izumo sperm-egg fusion 1 is a protein that in humans is encoded by the IZUMO1 gene. In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes. The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion. May 04, 2019  I had a fight with a Kreml in my Izumo at 9-10km. First salvo 1 pen,some bounce, 0dmg. Second salvo 3 pen,some bounce,0 dmg? Is this a joke or bug or hands of Stalin or what? 4 pens with no dmg? Thats ridiculous. Every surface is curved - there is hardly a straight line to be found. This pen is a study in simplicity which makes curves look easy. The mirror-like Kuro-tamenuri urushi lacquer finish highlights the shape. This surface is built up with multiple layers of natural lacquer to a tremendously hard finish. The clip, the only piece of trim exposed on the closed pen, does the.

Touma Hikaru is a student at the prestigious Izumo private academy. Recently he is troubled by dreams that always has the same woman trying to tell him something. One day, following the steps of the dream he had last night he goes to the abandoned building at the back of the school. When he touches a mirror there, there is a flash of bright light followed by an earthquake. He rushes out to the. Jun 25, 2015  Page 1 of 2 - Platinum Izumo Sora Tamenuri (Fine Nib) - posted in Fountain Pen Reviews: This stupid site; you cant spend any amount of time on it without deciding that you really need an urushi pen. So.thats where I am right now. Ive had a little time now with my new Platinum Izumo Sora tamenuri pen and Ive decided to write a little review.

Izumo sperm-egg fusion 1 is a protein that in humans is encoded by the IZUMO1 gene.^[5] In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes. ^[6]

Function[edit]

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion.^[7]

Studies have shown that male Izumo knockout mice are sterile because their sperm are unable to fuse to the oocyte membrane.[1] Izumo -/- mice produced morphologically normal sperm that were able to penetrate the zona pellucida, but could not fuse with to the eggs. In fact, it is necessary to relocate the IZUMO1 to the site of oocyte fusion ^[8]. In-vitro human experiments have also been conducted, suggesting that Izumo is required for human gamete fusion. [1]

Through the use of Western Blot analyses, it has been shown that Izumo is only expressed in the testis and is found on mature spermatozoa. ^[9] Izumo-1 located on mature spermatozoa that have undergone capacitation binds to its receptor Juno, which is located on the oolemma of eggs. ^[10]

References[edit]

1. ^ ^abcGRCh38: Ensembl release 89: ENSG00000182264 - Ensembl, May 2017
2. ^ ^abcGRCm38: Ensembl release 89: ENSMUSG00000064158 - Ensembl, May 2017
3. ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^'Entrez Gene: Izumo sperm-egg fusion 1'.
6. ^ Bianchi, Enrica, et al. 'Juno is the egg Izumo receptor and is essential for mammalian fertilization.' Nature 508.7497 (2014): 483.
7. ^Inoue N, Ikawa M, Isotani A, Okabe M (2005). 'The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs'. Nature. 434 (7030): 234–8. Bibcode:2005Natur.434.234I. doi:10.1038/nature03362. PMID15759005.
8. ^Ikawa, M., Inoue, N., Benham, A. M., & Okabe, M. (2010). Fertilization: a sperm's journey to and interaction with the oocyte. The Journal of clinical investigation, 120(4), 984-94.
9. ^ Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P. Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Molecular reproduction and development. 2009;76(12):1188-1199.
10. ^ Bianchi E, Doe B, Goulding D, Sanger Mouse Genetics Project, Wright GJ. Juno is the egg Izumo receptor and is essential for mammalian fertilisation. Nature. 2014;508(7497):483-487.

Further reading[edit]

• Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, Ngwa JS, Qi Q, Curhan GC, Rimm EB, Hunter DJ, Pasquale LR, Ridker PM, Hu FB, Chasman DI, Qi L (2013). 'Novel locus including FGF21 is associated with dietary macronutrient intake'. Human Molecular Genetics. 22 (9): 1895–902. doi:10.1093/hmg/ddt032. PMC3612009. PMID23372041.
• Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (2006). 'Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization'. Human Molecular Genetics. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID17047026.
• Granados-Gonzalez V, Aknin-Seifer I, Touraine RL, Chouteau J, Wolf JP, Levy R (2008). 'Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure'. Fertility and Sterility. 90 (4): 1246–8. doi:10.1016/j.fertnstert.2007.09.008. PMID18082733.
• Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, Primakoff P (2009). 'Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm'. Molecular Reproduction and Development. 76 (12): 1188–99. doi:10.1002/mrd.21092. PMC3779078. PMID19658160.
• Grayson P, Civetta A (2012). 'Positive Selection and the Evolution of izumo Genes in Mammals'. International Journal of Evolutionary Biology. 2012: 958164. doi:10.1155/2012/958164. PMC3432370. PMID22957301.
• Inoue N, Ikawa M, Okabe M (2008). 'Putative sperm fusion protein IZUMO and the role of N-glycosylation'. Biochemical and Biophysical Research Communications. 377 (3): 910–4. doi:10.1016/j.bbrc.2008.10.073. PMID18952059.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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