Dmg Stat Affect Dr Fetus
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Fetus is a reference to one of Edmund's other games, Super Meat Boy. In Ending 5, Isaac is shown dressed up as Dr. Fetus, accompanied by dramatic music and Isaac turning around, which is a reference to the Dramatic Chipmunk meme. Fetus has a 67% lower chance to appear in Hard Mode. May 02, 2017 Gives a range up and the explosion does aoe dmg (i would say 0.5.isaac's dmg). More hitbox of tears hight area of effect. Good synergies with objects like parasyte, cricket's body, compound bounds. Very big fireworks with both fetus. Rainbow brimstone. Both Brimstone and Ipecac shots modify Isaac's damage and tear delay stat, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone deals significantly increased damage. The beam is colored yellowish green. Take care to pre-charge Brimstone so that the Ipecac shot is on cooldown as Isaac enters a room.
- General
SPECIALTIES
- Maternal Fetal Medicine
- Years in Practice: 26
BOARD CERTIFICATIONS
- Maternal Fetal Medicine
- Obstetrics and Gynecology
PATIENTS SEEN
Accepts adultsLANGUAGES
- English
MEDICAL INTERESTS
High Risk Obstetrics, Fetal Echocardiography, Amniocentesis - Education
EDUCATION
School Oklahoma State University - College of Osteopathic Medicine
Graduation Date 05/1991
Degree D.O.INTERNSHIPS
School Hillcrest Health Center - Oklahoma CityRESIDENCY
School Hillcrest Health Center OB/GYN
Title Resident in Obstetrics and Gynecology
School St. Anthony Hospital Family Medicine
Title Resident in Family MedicineFELLOWSHIPS
School Rockford Memorial Hospital
Specialty Maternal Fetal Medicine - American Osteopathic Association
- American College of Obstetricians and Gynecologists
- American Institute of Ultrasound in Medicine
- Based on 65 reviews
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Dr. Taylor is my favorite maternal and fetal medicine Dr. He has treated me through 2 pregnancies. He is wonderful!!
Dr. Taylor is phenomenal. Even though he had to give me some not great news, he was so kind while doing it. He showed concern and understanding. I had lots of questions and he stood…See more
Dmg Stat Affect Dr Fetus 2
Abstract
Objective
To compare provider assessment of fetal maceration with death-to-delivery interval to evaluate the reliability of appearance as a proxy for time of death.
Methods
Cohort chart abstraction was performed for all stillbirth deliveries at or above 28 weeks of gestation during a 1-year period in a teaching hospital in Ghana.
Results
Of 470 stillborn infants, 337 had adequate data for analysis. Of 47 fetuses alive on admission with death-to-delivery intervals estimated to be less than 8 hours (expected to be reported as fresh), 14 (30%) were actually reported as macerated. Of 94 cases in which the fetus was deceased on admission with death-to-delivery interval of more than 8 hours (expected to be macerated), 17 (18%) were described as fresh.
Conclusion
Provider description of fetal appearance may be an unreliable indicator for time since fetal death. The findings have significant implications for stillbirth prevention and assessment.
1. Introduction
Stillbirth remains a severely understudied and grossly underreported problem in low-income countries [,]. Efforts to reduce unacceptably high stillbirth rates in low-income nations typically distinguish between deaths occurring prepartum (before labor) and those occurring intrapartum (during labor) []. Advocates have long assumed that fresh stillbirths occur shortly before delivery and so might be preventable based on changes in care, resources, education, or medical access [–]. These have often been considered the first priority for researchers because they may be “near misses,” which—in theory—might be avoidable losses if access to adequate and appropriate care were available to the mother in time.
A reliable method to identify the approximate time of death and the death-to-delivery interval is challenging to obtain in low-resource settings. In community studies, verbal autopsies utilize interviews with families to register out-of-hospital births and fetal deaths and recording the last time that the mother perceived fetal movement as a proxy for time of death [,]. In facility-based deliveries, death-to-delivery interval is generally based on fetal appearance, as assessed by the physician, nurse, or midwife at delivery. A “macerated” fetus shows skin and soft-tissue changes (skin discoloration or darkening, redness, peeling, and breakdown) suggesting death was well before delivery (prepartum) [,]. A “fresh” fetus lacks such skin changes and is presumed to have died much more recently (intrapartum). Recent case series from low-income countries have described cohorts of stillbirths delivered in hospital settings and have relied on fetal appearance to classify the death as prepartum versus intrapartum [–]. Unfortunately, there has been no research in low-income countries to study whether this is, in fact, a valid method of assessment.
The aim of the present study was to evaluate third-trimester stillbirths at a teaching hospital in Ghana over 1 year to compare provider assessment of fetal status at delivery (fresh or macerated) with the time between death and delivery according to medical records.
2. Materials and methods
From June 8, 2011, to June 12, 2012, we identified all stillbirths delivered at Komfo Anokye Teaching Hospital (KATH), which is one of the largest teaching hospitals in Ghana and is located in the center of the second largest city, Kumasi. We used WHO criteria to define stillbirth: fetal deaths delivered at 28 or more gestational weeks without signs of life at delivery [14]. The study was part of a broader investigation of risk factors associated with stillbirth. We hypothesized that the labeling of a fetus as fresh would correlate well with less than 8 hours since death, and macerated would correlate with at least 8 hours between death and delivery. The study was approved by the institutional review board at the University of Michigan and the Committee on Human Research Publication and Ethics of the Kwame Nkrumah University of Science and Technology in Kumasi, which governs research at KATH. Written informed consent was not required and data were de-identified. Reporting was based on STROBE guidelines [].
The primary reviewer (A-R.S.A-M.) visited the wards several times weekly throughout the year to collect data from paper charts and to discuss cases with the midwives on duty in order to fill-in missing data and assess issues with staffing and personnel availability during the time of the patient's stay. For each fetal death, the reviewer abstracted the mother's chart to identify maternal demographics and past medical history; prior pregnancy outcomes; prenatal care and labs in the current pregnancy; referral source; admission data; delivery information; complications; and potential contributors to death. A second reviewer (K.J.G., M.E.B.) re-abstracted data from approximately 30% of charts to ensure accuracy, to fill-in missing data points, and to confirm outlying data. Data were initially recorded on a written datasheet and then entered into a computer database (Access version 14; Microsoft, Redmond, WA, USA) and triple-checked for data entry accuracy.
In most cases, we could identify whether the fetus was alive at admission to the hospital (yes/no) and the status on admission (whether in labor and whether membranes intact). Time of last fetal movement and time of labor onset were not documented for most cases, so we could rarely identify whether pre-hospital deaths were prepartum or intrapartum. We also coded whether the fetus was identified as fresh or macerated based on the delivering team's (physician or nurse–midwife) assessment of the infant recorded in the paper chart.
For all deaths, we collected information (when available) documenting day and time of admission, last documented positive fetal heart rate (FHR—recorded at the study hospital via ultrasound, Doppler, or fetoscope), time when intrauterine fetal demise (IUFD) was diagnosed, and time of delivery. While we had admission and delivery dates for most infants, data on last FHR and time of fetal death were limited, and in most cases applied to infants who were alive on admission.
In some cases, it was unclear from charts whether the fetus was alive on admission, and not all deliveries listed fetal condition at delivery; therefore, from the initial 470 fetal deaths, we restricted our analysis to cases for which these data were available. This left 337 stillborn fetuses in the cohort for analysis (72% of the original dataset).
When the fetus was dead on admission, we assigned the time of death as the time of admission unless we had additional information (e.g. ultrasound prior to admission) that confirmed the time of IUFD. If we had an ultrasound documenting a live infant prior to admission, we calculated both a minimum death-to-delivery interval (time from IUFD diagnosis until delivery) and a maximum death-to-delivery interval (1 hour after the last positive FHR was recorded).
When the fetus was alive on admission and the FHR was not rechecked before delivery, we assigned the time of death as 1 hour after the last documented FHR. If the infant was alive on admission and then diagnosed as IUFD during labor, we calculated a minimum death-to-delivery interval as time between IUFD confirmation and delivery. We calculated the maximum death-to-delivery interval as 1 hour after the last positive FHR and delivery. Sample cases illustrating calculation of minimum and maximum death-to-delivery intervals are described in Figure 1.
Calculation of minimum and maximum death-to-delivery intervals for sample cases. Abbreviations: IUFD, intrauterine fetal demise; FHR, fetal heart rate.
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We used 8 hours as our cutoff time based on the most commonly used maceration criteria described by Langley []; this is also the timing mentioned in the practice guidelines for perinatal autopsy for the Autopsy Committee of the College of American Pathologists []. If both the minimum and the maximum death-to-delivery intervals were less than 8 hours or both were more than 8 hours, the classification was straightforward. In a small number of cases, the minimum death-to-delivery interval was less than 8 hours and the maximum was more than 8 hours; in such cases, we reviewed the clinical scenario and determined the most probable timing.
Analysis to evaluate summary statistics was performed using STATA/IC version 11.0 (StataCorp, College Station, TX, USA).
3. Results
There were 465 mothers who delivered a stillborn fetus at 28 weeks or later at KATH during the study period (Table 1). Two-thirds of pregnancies were dated by fetal ultrasound and the rest by last menstrual period. Of these mothers, 443 (95%) had a singleton pregnancy, 20 had twins, and 2 had triplets. In most cases with multiples, only 1 fetus died. In 5 cases (all twin deliveries), both fetuses died. This resulted in a total of 470 stillborn fetuses. As noted, the analysis was restricted to the 337 fetuses with adequate data for analysis. The maternal demographics of this subgroup were not substantially different from those of the full group of mothers in the dataset.
Table 1
Demographics of women (n=465) who delivered stillborn fetusesa
Characteristic | Value |
---|---|
Age, y | 29 ± 6 (14–46) |
Marital status | |
Married | 194 (41.7) |
Living together | 92 (19.8) |
Never married | 95 (20.4) |
Widowed | 1 (0.2) |
Data missing | 83 (17.8) |
Primary residence | |
Urban | 317 (68.2) |
Rural | 44 (9.5) |
Data missing | 104 (22.4) |
Education | |
None | 65 (14.0) |
Primary school | 165 (35.5) |
Middle or junior secondary school | 161 (34.6) |
Senior secondary school or higher | 38 (8.2) |
Data missing | 36 (7.7) |
For the 71 fetuses identified as being alive on admission, the time between death and delivery ranged from 0 to 275 hours (Figure 2). In 47 cases, the death-to-delivery interval was less than 8 hours: 33 (70%) fetuses were fresh and 14 (30%) were macerated. In 20 cases, the death-to-delivery interval was more than 8 hours, half of which were fresh and half macerated. In 4 cases, the death-to-delivery interval (more than or less than 8 hours) could not be definitively determined, so these cases were not analyzed.
Distribution of fresh and macerated stillbirths according to death-to-delivery interval.
Of the 266 fetuses that were dead on admission, 172 had less than 8 hours from admission to delivery but we could not rule out the possibility that the fetus had died long before the mother presented to the hospital. Therefore, these cases were not analyzed. Of the 94 fetuses with a death-to-delivery interval of at least 8 hours, 17 (18%) were reported as fresh, including many known to have been dead 24 hours or more, and 77 (82%) were reported as macerated.
The Wigglesworth criteria for cause of death in cases of stillbirth exclude fetuses with visible congenital anomalies [,]. We chose not to exclude fetuses with anomalies (n=21) because these were a small subset of the overall total and their classifications were not significantly different from the overall set of stillbirths.
4. Discussion
The present study demonstrated that appearance may not be an accurate proxy for death-to-delivery interval or prepartum versus intrapartum demise. Particularly among fetuses noted to be alive on admission to the hospital, one-third of those that would be anticipated to be fresh stillbirths were reported as macerated, and half of those that would be expected to be macerated were actually described as fresh.
When a fetus dies in utero, there are changes in the skin and tissues—termed fetal maceration. This process takes place entirely in the womb and stops once the fetus is delivered [,]. The phenomenon of maceration was first described in 1922 as loss of the vernix and then skin peeling []. In 1971, Langley [] discussed levels of maceration and noted that peeling skin is associated with death of at least 8 hours; this is the most common classification system utilized. Practice guidelines for perinatal and pediatric autopsy by the Autopsy Committee of the College of American Pathologists also uses the 8-hour cutoff []. Genest and Singer [] identified 60 fetuses for which exact times of death and delivery were known and photographs were available. The authors described detailed changes in skin color, desquamation, and collapse of the skull based on death-to-delivery interval. Early signs of maceration (desquamation of more than 1 cm and red/brown cord discoloration) began at 6 hours post-death. However, in their study (the only one in the literature to make this comparison), death-to-delivery interval was miscalculated in almost one-third of 26 “test” photographs of stillborn fetuses. These same criteria were recently used in a major US study on stillbirth []. A key reference book for fetal pathology also mentions 6–8 hours as the earliest point when signs of maceration are seen [22].
Most studies of stillbirth that evaluate maceration do so without detailing a specific definition. Lawn et al. [] reported that a fresh stillbirth implies death less than 12 hours before delivery, but this appears to be a clinical judgment. Maceration is a subjective diagnosis; while all providers are likely to describe a fetus with extensive skin desquamation and skull collapse as macerated, categorization may be less clear for a fetus with minor skin changes or skin slippage.
Maceration can also be an imprecise predictor of timing of death for technical reasons. High microbial load in the amniotic fluid, long duration of hypoxia prior to actual death, and maternal fever might all contribute to more maceration than would otherwise be expected for a certain death-to-delivery interval. Many studies describe the rate of postmortem human decomposition, but none describes detailed events between IUFD and delivery. We can, however, extrapolate basic theories about factors that accelerate human decomposition to those impacting fetal demise. Most notably, autolytic changes may occur faster under the increased temperature with maternal hyperthermia/sepsis associated with prolonged rupture of membranes. Similarly, if the fetal death is a result of fulminating bacterial infection (chorioamnionitis due to prolonged rupture of membranes), accelerated putrefaction (decomposition) can also be expected [23].
In community-based studies, verbal autopsy is used to estimate population-based rates of stillbirth by asking women when fetal movement stopped [,]. One study on the accuracy of verbal autopsy in 311 cases of stillbirth suggested that verbal autopsy and hospital-identified time of stillbirth were in concordance in 94% of prepartum deaths and 85% of intrapartum deaths, although the study used only fetal appearance of fresh versus macerated for some of the cases []. Ellis et al. [] utilized verbal autopsy to compare maternal report of when fetal movement stopped with maternal description of the fetus as fresh or macerated. Of 201 fetuses moving when labor started, 24% were described as macerated. Of the 117 fetuses not moving when labor started, 34% were described as fresh.
The present study had several limitations. First, the quality of medical chart data in low-resource settings is variable and key data points were often not recorded, so the cases were excluded. This is a widespread barrier to data collection in low-income countries and reflects the reality of the working conditions and the challenges to conducting research in countries with the highest need for data. Second, the analysis was performed at a major hospital with 14 000 deliveries each year. Like most hospitals in Sub-Saharan Africa with this volume of deliveries, there was no equipment for continuous monitoring of FHR, which would allow precise estimation of time of death. Third, there were a limited number of midwives and physicians at the study hospital and throughout Ghana so, even with intermittent monitoring, there can be long gaps between assessments of FHR. Fourth, no stillborn fetus in the present study had a postmortem autopsy, which would have allowed more precise identifications of time of death and fetal appearance.
Strengths of the study included the capture of all stillbirths over a 1-year period at a large urban hospital, as well as collection of systematic data on maternal demographics and risk factors, pregnancy care, delivery complications, and hospital variables. Few hospital-based studies collect such detailed information, despite it enabling richer understanding of these deaths.
The present large and comprehensive study to assess fetal appearance as a predictor of death-to-delivery interval indicates that such practice may be problematic. Although intrapartum fetal demise has been seen as a prime target for stillbirth prevention, we would caution against assuming that fetal appearance accurately indicates intrapartum deaths. Health facilities in low-income countries have enormous resource challenges to providing clinical care, and data collection is often a low priority. However, as the present study shows, medical records that identify accurate timing of positive FHR and diagnosis of fetal demise could provide critical data to focus efforts toward measuring and improving stillbirth outcomes worldwide.
The description of a stillborn fetus as fresh or macerated, commonly used in low-income countries, may be an unreliable indicator for time since fetal death.
Acknowledgments
Funding for travel was provided by grants from the University of Michigan Global REACH office and the University of Michigan Institute for Research on Women and Gender. K.J.G. received salary support from the National Institutes of Health as part of a K-23 training grant. No funder had a role in analysis of results or preparation/review of the manuscript.
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Footnotes
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Conflict of interest
The authors have no conflicts of interest.