N N Dimethylglycine Hcl Dmg

Dimethylglycine

Mar 04, 2015 Dimethylglycine, also known as DMG, is an amino acid found in small amounts throughout the body. Today, dimethylglycine is used primarily in nutritional supplements and medicine. Find out everything you need to know about Dimethylglycine today in our DMG review! What is Dimethylglycine? Dimethylglycine is a derivative of an amino acid called. Dimethylglycine is a highly unusual supplement, in that it is extremely popular despite the fact that all of its touted effects have largely been refuted by clinical and laboratory testing.

Sep 17, 2019 Dimethylglycine might be safe to use short-term, up to 28 days. The safety of long-term use is unknown. Special Precautions & Warnings: Pregnancy and breast-feeding: Not enough is known about the use of dimethylglycine during pregnancy and breast-feeding.

Dimethylglycine
Names
IUPAC name
Other names
N,N-Dimethylglycine
Identifiers
  • 1118-68-9
3DMet
1700261
ChEBI
ChemSpider
  • 653
DrugBank
ECHA InfoCard100.012.971
EC Number
  • 214-267-8
82215
KEGG
  • C01026
MeSHdimethylglycine
RTECS number
CompTox Dashboard(EPA)
  • InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
  • CN(C)CC(O)=O
Properties
C4H9NO2
Molar mass103.121 g·mol−1
AppearanceWhite crystals
OdorOdourless
Density1.069 g/mL
Melting point 178 to 182 °C (352 to 360 °F; 451 to 455 K)
Boiling point 175.2 °C (347.4 °F; 448.3 K)
Hazards
GHS pictograms
GHS Signal wordWarning
H302
Lethal dose or concentration (LD, LC):
>650 mg kg−1(oral, rat)
Related compounds
Related alkanoic acids
Dimethylacetamide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Dimethylglycine (DMG) is a derivative of the amino acidglycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline. El capitan download.

Dmg

When DMG was first discovered, it was referred to as Vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects and it is synthesized by the human body in the citric acid (or Krebs) cycle meaning it does not meet the definition of a vitamin.

Uses[edit]

N N-dimethylglycine Hcl (dmg)

Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease.[2] There is no evidence that dimethylglycine is effective for treating mitochondrial disease.[3] Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.[4][5]

Biological activity[edit]

N N Dimethylglycine Dmg

Dimethylglycine has been found to act as an agonist of the glycine site of the NMDA receptor.[6]

Preparation[edit]

This compound is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may have been obtained by neutralization of the acid salt, which has been performed with silver oxide.[7]

H2NCH2COOH + 2 CH2O + 2 HCOOH → (CH3)2NCH2COOH + 2 CO2 + 2 H2O

N N-dimethylglycine For Cats

References[edit]

N Dimethylglycine Dmg Side Effects

  1. ^'dimethylglycine - Compound Summary'. PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. Identification. Retrieved 24 April 2012.
  2. ^'Dimethylglycine'. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. December 8, 2009.
  3. ^Pfeffer, Gerald; Majamaa, Kari; Turnbull, Douglass M.; Thorburn, David; Chinnery, Patrick F. (2012-04-18). 'Treatment for mitochondrial disorders'. The Cochrane Database of Systematic Reviews (4): CD004426. doi:10.1002/14651858.CD004426.pub3. ISSN1469-493X. PMID22513923.
  4. ^Bolman WM, Richmond JA (June 1999). 'A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder'. Journal of Autism and Developmental Disorders. 29 (3): 191–4. doi:10.1023/A:1023023820671. PMID10425581.
  5. ^Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). 'Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder'. Journal of Child Neurology. 16 (3): 169–73. doi:10.1177/088307380101600303. PMID11305684.
  6. ^Lin, Jen-Cheng; Chan, Ming-Huan; Lee, Mei-Yi; Chen, Yi-Chyan; Chen, Hwei-Hsien (2016). 'N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice'. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 71: 7–13. doi:10.1016/j.pnpbp.2016.06.002. ISSN0278-5846. PMID27296677.
  7. ^Clarke, H. T.; Gillespie, H. B.; Weisshaus, S. Z. (1933). 'The Action of Formaldehyde on Amines and Amino Acids'. Journal of the American Chemical Society. 55 (11): 4571. doi:10.1021/ja01338a041.
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